What is EBOO therapy?

EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. It is a physician-supervised therapy that circulates blood through a specialized closed-loop filtration system outside the body, where it is exposed to medical-grade oxygen and ozone before being returned to the bloodstream. It is a more advanced approach than traditional ozone autohemotherapy, treating a larger volume of blood continuously and incorporating filtration throughout the session.

How is EBOO different from standard ozone IV therapy?

Traditional ozone therapy treats a small amount of blood at a time. EBOO uses a dialysis-like closed-loop system allowing continuous circulation, filtration, oxygenation, and ozonation throughout the session — resulting in greater blood volume exposure, more intensive monitoring, and a more comprehensive process overall.

What can EBOO therapy support?

EBOO is used as part of a personalized integrative medicine plan to support recovery and performance optimization, healthy inflammatory balance, circulatory health, immune support after acute illness, energy and vitality, detoxification pathways, and general longevity strategies. EBOO is not intended to diagnose, treat, cure, or prevent any disease. Ozone therapies are not FDA-approved for specific disease treatment. Individual results vary.

What happens during an EBOO session?

Two IV lines are placed to create a sterile closed-loop system. Blood is gently circulated through the EBOO device, passing through specialized filtration while exposed to medical-grade oxygen and ozone, then returned to the body. Sessions are physician-monitored and typically last 60 to 90 minutes.

How much does EBOO therapy cost at Makena Health?

A single EBOO session costs $1,200. A 5-pack is $5,000 and a 10-pack is $9,500. GET (Hawaii General Excise Tax) is not included in EBOO pricing. Members receive a 20% discount. A full medical evaluation is required before the first treatment — this evaluation is complimentary for Makena Health members.

How many EBOO sessions are recommended?

For acute or subacute health concerns, the standard protocol is once weekly for 3 consecutive weeks, then once monthly. For maintenance and general wellness, once monthly or once every few months. Frequency is always determined by Dr. Starbuck based on individual goals and clinical status.

Who is not a good candidate for EBOO?

EBOO is not appropriate for patients with significant anemia, active bleeding disorders, G6PD deficiency, active use of blood thinners or known coagulopathy, cardiovascular instability, or pregnancy and breastfeeding. Medical clearance from Dr. Starbuck is required before every treatment.

What should I expect after an EBOO session?

Some patients feel tired the day of treatment. Day two and beyond, most report improved mental clarity, cleaner energy, and an overall sense of feeling better. Individual response varies.

EBOO Therapy in Maui

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EBOO (Extracorporeal Blood Oxygenation and Ozonation) is an advanced physician-supervised therapy that circulates blood through a specialized closed-loop filtration system outside the body, where it is exposed to medical-grade oxygen and ozone before being returned to the bloodstream. Unlike standard ozone IV therapy, EBOO treats a larger volume of blood continuously during one session and includes an advanced filtration process designed to support circulation, oxidative balance, and overall wellness. PubMed literature describes EBOO as a more advanced extracorporeal ozone therapy approach compared with traditional autohemotherapy.
Traditional ozone therapy typically treats a small amount of blood at a time through major autohemotherapy (MAH). EBOO is more comprehensive, using a dialysis-like filtration system that allows continuous blood circulation, filtration, oxygenation, and ozonation throughout the session.
This allows for:
• Greater blood volume exposure during treatment
• Advanced filtration support
• Continuous oxygenation and circulation support
• A more intensive physician-monitored wellness therapy
EBOO is used as part of a personalized functional & integrative medicine plan to support:
• Recovery and performance optimization
• Healthy inflammatory balance
• Circulatory health
• Immune system support, especially after acute illness
• Energy and vitality
• Detoxification pathways and oxidative stress management
• General wellness and longevity strategies
EBOO is not intended to diagnose, treat, cure, or prevent any disease. In the United States, ozone therapies are not FDA-approved for specific disease treatment claims, and therapy should be discussed with a qualified medical professional.
Two IV lines are placed to create a sterile closed-loop system. Blood is gently circulated through the EBOO system, where it passes through specialized filtration while being exposed to medical-grade oxygen and ozone before returning to the body.
Sessions are carefully monitored by trained medical professionals and typically last approximately 60–90 minutes depending on the protocol.
Because the blood remains within a closed sterile system, contamination risk is minimized.
EBOO may be appropriate for individuals seeking advanced wellness optimization, recovery support, or integrative longevity strategies. It may also be considered for those looking to support systemic inflammation balance, circulation, and overall resilience as part of a broader physician-guided plan.
A full medical evaluation is required before treatment to determine candidacy.
EBOO may not be appropriate for individuals with certain medical conditions including:
• Significant anemia
• Active bleeding disorders
• G6PD deficiency
• Actively using blood thinners or known coagulopathy
• Cardiovascular instability
• Pregnancy or breastfeeding (case-dependent)
Medical clearance is required before treatment.
When performed in a properly supervised clinical environment using a sterile closed-loop medical system, EBOO is safe & well tolerated. At Makena Health, we utilize extensive medical screening, physician evaluation, and rigorous safety protocols before every treatment to ensure appropriate candidacy and maximize safety. As with any IV-based medical therapy, potential risks may include bruising, fatigue, lightheadedness, vein irritation, or temporary post-treatment fatigue.
Recommendations vary based on individual goals, overall health status, and clinical context. For general wellness, recovery, and longevity support, many individuals pursue EBOO periodically, often once every few months as part of a broader proactive health strategy. For those addressing more complex or chronic health concerns, a more structured initial series is commonly recommended, such as one session weekly for three consecutive weeks, followed by maintenance sessions approximately once monthly. Treatment frequency is determined by the Makena Health team.

Schedule EBOO Today

EBOO and ozone-based therapies have not been approved by the U.S. Food and Drug Administration for the diagnosis, treatment, cure, or prevention of any disease. At present, there are no large-scale randomized placebo-controlled clinical trials establishing definitive clinical outcomes for EBOO therapy. Current evidence consists primarily of mechanistic research, physiologic rationale, observational studies, international clinical experience, and practitioner-reported outcomes. Individual responses may vary, and specific results cannot be guaranteed. EBOO is offered as an adjunctive wellness and recovery therapy and is not intended to replace conventional medical evaluation or treatment.

This therapy is part of our comprehensive Longevity Medicine Program at Makena Health.

EBOO Therapy in Maui

What is EBOO?

How is EBOO Different from Traditional Ozone Therapy?

What Can EBOO Support?

What Happens During Treatment?

Who is a candidate for EBOO Therapy at Makena Health?

Who Should Avoid EBOO?

Is EBOO Safe?

How Many Sessions Are Recommended?