EBOO (Extracorporeal Blood Oxygenation and Ozonation) is an advanced physician-supervised therapy that circulates blood through a specialized closed-loop filtration system outside the body, where it is exposed to medical-grade oxygen and ozone before being returned to the bloodstream. Unlike standard ozone IV therapy, EBOO treats a larger volume of blood continuously during one session and includes an advanced filtration process designed to support circulation, oxidative balance, and overall wellness. PubMed literature describes EBOO as a more advanced extracorporeal ozone therapy approach compared with traditional autohemotherapy.

Traditional ozone therapy typically treats a small amount of blood at a time through major autohemotherapy (MAH). EBOO is more comprehensive, using a dialysis-like filtration system that allows continuous blood circulation, filtration, oxygenation, and ozonation throughout the session.

This allows for:

• Greater blood volume exposure during treatment
• Advanced filtration support
• Continuous oxygenation and circulation support
• A more intensive physician-monitored wellness therapy

EBOO is used as part of a personalized functional & integrative medicine plan to support:

• Recovery and performance optimization
• Healthy inflammatory balance
• Circulatory health
• Immune system support, especially after acute illness
• Energy and vitality
• Detoxification pathways and oxidative stress management
• General wellness and longevity strategies

EBOO is not intended to diagnose, treat, cure, or prevent any disease. In the United States, ozone therapies are not FDA-approved for specific disease treatment claims, and therapy should be discussed with a qualified medical professional.

Two IV lines are placed to create a sterile closed-loop system. Blood is gently circulated through the EBOO system, where it passes through specialized filtration while being exposed to medical-grade oxygen and ozone before returning to the body.

Sessions are carefully monitored by trained medical professionals and typically last approximately 60–90 minutes depending on the protocol.

Because the blood remains within a closed sterile system, contamination risk is minimized.

EBOO may be appropriate for individuals seeking advanced wellness optimization, recovery support, or integrative longevity strategies. It may also be considered for those looking to support systemic inflammation balance, circulation, and overall resilience as part of a broader physician-guided plan.

A full medical evaluation is required before treatment to determine candidacy.

EBOO may not be appropriate for individuals with certain medical conditions including:

• Significant anemia
• Active bleeding disorders
• G6PD deficiency
• Actively using blood thinners or known coagulopathy
• Cardiovascular instability
• Pregnancy or breastfeeding (case-dependent)

Medical clearance is required before treatment.

When performed in a properly supervised clinical environment using a sterile closed-loop medical system, EBOO is safe & well tolerated. At Makena Health, we utilize extensive medical screening, physician evaluation, and rigorous safety protocols before every treatment to ensure appropriate candidacy and maximize safety. As with any IV-based medical therapy, potential risks may include bruising, fatigue, lightheadedness, vein irritation, or temporary post-treatment fatigue.

Recommendations vary based on individual goals, overall health status, and clinical context. For general wellness, recovery, and longevity support, many individuals pursue EBOO periodically, often once every few months as part of a broader proactive health strategy. For those addressing more complex or chronic health concerns, a more structured initial series is commonly recommended, such as one session weekly for three consecutive weeks, followed by maintenance sessions approximately once monthly. Treatment frequency is determined by the Makena Health team.